Effective for new coronary pneumonia treatment, what is the "old drug" chloroquine phosphate?
Because it is an old medicine, the safety is
guaranteed.
On February 15th, Zhang Xinmin, director of the Biological
Center of the Chinese Ministry of Science and Technology, mentioned in a press
conference that scientists have conducted multiple drug screenings for new
coronaviruses, gradually focusing on drugs such as chloroquine phosphate and redcive.
Two days later, That is, on February 17, Sun Yanrong, deputy director of the
Biological Center of the Ministry of Science and Technology, China once again
mentioned chloroquine phosphate in a press conference-research shows that it is
effective for the treatment of new coronary pneumonia.
What exactly is chloroquine phosphate?
Chloroquine phosphate and chloroquine are basically the same
thing, or put it this way:
Most of the chloroquine available on the market
today is chloroquine phosphate. In the 1930s, German scientists synthesized
Chloroquine to treat malaria.
Later, scholars discovered that if a phosphate is
added to chloroquine, its stability and absorption will increase, so
Chloroquine phosphate is available.
Malaria is a kind of flicking that people often say, caused
by the malaria parasite.
Plasmodium is a very weird creature that can live in
the stomach of mosquitoes and in the liver cells of the human body, the
favorite is parasitic in red blood cells.
However, weirdness is weird.
Plasmodium is inseparable from protein like all living things. It must obtain
enough essential amino acids by digesting hemoglobin.
Chloroquine can enter the
malaria parasite, interfere with its digestive system, and slowly starve them
to death.
How does chloroquine relate to viruses?
Before artemisinin was born, chloroquine was the most
commonly used antimalarial drug; even after artemisinin appeared, it was still
the drug of choice for preventing malaria.
In a long period of clinical
practice, doctors slowly discovered that this drug seems to be able to deal
with the virus.
Plasmodium is already weird enough, but it is just a weird
lifestyle. On the structure, the virus is the most peculiar life form.
Taking
coronavirus as an example, it does not have any normal cell structure, and it
depends on others when eating and drinking.
Once it meets a suitable cell, the coronavirus uses a spike
to bind to a specific receptor on the surface of the cell (angiotensin convertingenzyme 2, ACE2) and enters the cell body.
Then, the shell is removed and the
genetic material is exposed.
Then use the organelles in normal cells to
synthesize the proteins and genetic material they need to complete
self-replication.
Finally, like blowing soap bubbles, gradually move out of the
cell.
Such an exquisite reproduction method is naturally
inseparable from the appropriate environment.
Virus unshelling and release
require appropriate pH (pH), and chloroquine can just change the pH of the
cell. Studies have shown that it can prevent the virus from exposing genetic
material. Without exposing the genetic material, the virus cannot replicate;
there is also evidence that it can prevent the virus from being released, and
the virus cannot infect other cells without being released outside the cell.
The most important evidence comes from 2005. Scholars have discovered that
chloroquine can weaken the binding of SARS virus to receptors. Without the
combination, the SARS virus has no way to enter the cell body, and infection is
naturally impossible to talk about.
To sum up, research in the past dozen years or so, shows that
chloroquine is a promising broad-spectrum antiviral drug that can reduce the
impact of viruses on the human body through a variety of mechanisms.
Chloroquine Compared with other emerging drugs, it also has a special advantage:
Chloroquine has
been clinically active for decades, the safety is more accurate, and the
adverse reactions are not only known and the incidence is extremely low.
There
are even studies showing that even high doses during pregnancy are not harmful.
Therefore, in the face of this new coronavirus, scholars
naturally think of chloroquine.
However, as mentioned in the previous article,
it depends on the experiment to see how it works.
Author's Bio
 |
| Dr. Shawna Reason |
Education: MBBS, MD
Occupation: Medical Doctor / Virologist
Specialization: Medical Science, Micro Biology / Virology, Natural Treatment
Experience: 15 Years as a Medical Practitioner
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