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Chloroquine Company is Urgently resuming production for Supply

At the press conference of the joint prevention and control mechanism of the new coronavirus infection pneumonia epidemic, Zhao Shitang, deputy secretary-general and press spokesman of the State-owned Assets Supervision and Administration Commission of the State Council, said that the central enterprise's anti-epidemic drug "chloroquine phosphate" accelerated production reserves, general technology The group's Chinese medicine is stepping up efforts to resume the production of chloroquine phosphate. 

Currently, it is increasing its horsepower to ensure market supply, and preparations can be produced by the end of February.
China Resources Group is still increasing reserves based on the existing inventory of 325,000 boxes of chloroquine related products.

Production of chloroquine phosphate now

Affected by this, the stock price of China Pharmaceutical (600056) rose sharply on February 18 and hit the daily limit. 
It is reported that chloroquine phosphate is listed as one of the Wuhan epidemic prevention and control drugs, and China Pharmaceuticals has urgently started its shareholding company, Chongqing Pharmaceutical Southwest Pharmaceutical No. 2 Factory, to prepare for the resumption of production of chloroquine phosphate. Currently, the raw materials have been organized and ready for production. Can be fully supplied.

Simulation for Chloroquine demand due to COVID-19

In addition, on the evening of February 17, Baiyunshan (600332) announced that its holding subsidiary, Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd., had received the "Approval of Drug Supplement Application" for chloroquine phosphate tablets approved and issued by the Guangdong Provincial Food and Drug Administration. 
Effective during the epidemic period. After the drug has passed the inspection of a batch of products by the Guangdong Provincial Drug Inspection Institute, it can be produced on the market according to the batch.

It is reported that Guanghua Pharmaceutical obtained the registration certificate and production approval of the chloroquine phosphate tablets approved by the Guangdong Provincial Department of Health in 1977, the re-registration approval in 2015, and the national drug transfer approval number in 2002. 

Now according to the requirements of relevant laws and regulations to apply for the resumption of production and obtain "drug supplement application approval". 

Guanghua Pharmaceutical has produced 500,000 chloroquine phosphate tablets and is in the second batch of about 500,000 tablets.

Chloroquine generally refers to chloroquine phosphate

Hydroxychloroquine sulfate is an improved version of chloroquine phosphate, also known as hydroxychloroquine. It has been on the market as a treatment for rheumatoid arthritis and other diseases for many years. Its structure and mechanism of action are similar to chloroquine phosphate, and it has better safety, so it is widely used in clinical practice to replace chloroquine phosphate. 

In 1999, hydroxychloroquine sulfate "Fanle" produced by Shanghai Pharmaceuticals was the first to be listed in China.

 In the first half of 2019, Shanghai Pharmaceutical's hydroxychloroquine achieved sales revenue of 384 million yuan (accounting for 0.41% of the company's current revenue), a year-on-year increase of 19.99% and a market share of 76.67%. 

In 2018, the company's hydroxychloroquine tablet revenue was 620.9 million yuan. On February 3, its wholly-owned subsidiary Shanghai Shangyao Zhongxi Pharmaceutical resumed production in accordance with the requirements of the Ministry of Industry and Information Technology.

On February 10, the first batch of 400,000 tablets of chloroquine phosphate was produced

Information from China's clinical trial platform shows that there are currently only eight domestic approvals for hydroxychloroquine sulfate, including one listed company Fuan Pharmaceutical (300194). 

Fuan Pharmaceutical is a national key high-tech enterprise mainly engaged in the research, development, production and sales of monocyclic β-lactams, penicillins and cephalosporin antibiotic raw materials and preparations.

It is expected to realize net profit attributable to shareholders of listed companies in 2019 From 290 million yuan to 295 million yuan, a year-on-year increase of 17.52% -19.54%.

It is understood that many domestic pharmaceutical companies hold chloroquine phosphate production approvals, but because of the low price and low demand for this drug, most companies do not produce it. At present, the above-mentioned large enterprises have resumed production.


Author's Bio

Doctor Shawna Reason, Virologist
Dr. Shawna Reason
Name: Shawna Reason

Education: MBBS, MD

Occupation: Medical Doctor / Virologist 

Specialization: Medical Science, Micro Biology / Virology, Natural Treatment

Experience: 15 Years as a Medical Practitioner

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